Obesity in Patients with Chronic Obstructive Pulmonary Disease as a Separate Clinical Phenotype

Main Article Content

Daria A Prokonich
Tatiana V Saprina
Ekaterina B Bukreeva

Abstract

Chronic obstructive pulmonary disease (COPD) is a heterogeneous, progressive disease characterized not only by pathological changes in the lungs but also by significant extrapulmonary manifestations and serious concomitant diseases. The current problem for the study is the features of the relationship between COPD and adipose tissue since there are contradictory data in the literature. This review presents studies that claim that obesity aggravates the course of COPD, as well as the results of studies that describe the “obesity paradox” in patients with COPD. Due to the lack of unambiguous data, it is necessary to continue studying this problem to optimize the tactics of managing this group of patients and draw up clear recommendations for patients with COPD.

Article Details

Prokonich, D. A., Saprina, T. V., & Bukreeva, E. B. (2024). Obesity in Patients with Chronic Obstructive Pulmonary Disease as a Separate Clinical Phenotype. Journal of Pulmonology and Respiratory Research, 8(2), 053–055. https://doi.org/10.29328/journal.jprr.1001060
Mini Reviews

Copyright (c) 2024 Prokonich DA, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2024 Report). 2024. Available from: https://goldcopd.org/

Akparova AY, Abdrakhmanova BM, Imanbay AK, Kazhiyahmetova BB, Bersimbay RI. Features of the pathogenesis of chronic obstructive pulmonary disease and its comorbid conditions. Vestnik KazNMU. 2019;(1):283–287.

Dedov II, Mel’nichenko GA, Butrova SA. Adipose tissue as an endocrine organ. Obesity and metabolism. 2006;3(1):6–13. Available from: https://doi.org/10.14341/2071-8713-4937

Unamuno X, Gómez-Ambrosi J, Rodríguez A, Becerril S, Frühbeck G, Catalán V. Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur J Clin Invest. 2018;48(9): e12997. Available from: https://doi.org/10.1111/eci.12997

Gould JM, Weiser JN. Expression of C-reactive protein in the human respiratory tract. Infect Immun. 2001;69(3):1747–1754. Available from: https://doi.org/10.1128/iai.69.3.1747-1754.2001

Ovsyannikov ES, Avdeev SN, Budnevsky AV. Systemic inflammation in patients with chronic obstructive pulmonary disease and obesity. Therapeutic archive. 2020;92(3):13–18. Available from: https://doi.org/10.26442/00403660.2020.03.000265

Fabbri LM, Rabe KF. From COPD to chronic systemic inflammatory syndrome? Lancet. 2007;370:797–799. Available from: https://doi.org/10.1016/S0140-6736(07)61383-X

Austin V, Crack PJ, Bozinovski S, Miller AA, Vlahos R. COPD and stroke: are systemic inflammation and oxidative stress the missing links? Clin Sci (Lond). 2016;130(13):1039–1050. Available from: https://doi.org/10.1042/CS20160043

Agustí A, Edwards LD, Rennard SI, MacNee W, Tal-Singer R, Miller BE, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype. PloS ONE. 2012;7(5):e37483. Available from: https://doi.org/10.1371/journal.pone.0037483

Rodrigues F, Papoila AL, Ligeiro D, Gomes MJ, Trindade H. Acute exercise amplifies inflammation in obese patients with COPD. Rev Port Pneumol. 2016;22(6):315–322. Available from: https://doi.org/10.1016/j.rppnen.2016.05.005

Garcia-Aymerich J, Gómez FP, Benet M, Farrero E, Basagaña X, Gayete À, et al. PAC-COPD Study Group. Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes. Thorax. 2011;66(5):430–437. Available from: https://doi.org/10.1136/thx.2010.154484

He H, Wang B, Zhou M, Cao L, Qiu W, Mu G, et al. Systemic inflammation mediates the associations between abdominal obesity indices and lung function decline in a Chinese general population. Diabetes Metab Syndr Obes. 2020;13:141–150. Available from: https://doi.org/10.2147/dmso.s229749

Mayoral LP, Andrade GM, Mayoral EP, Huerta TH, Canseco SP, Rodal Canales FJ, et al. Obesity subtypes, related biomarkers & heterogeneity. Indian J Med Res. 2020;151(1):11-21. Available from: https://doi.org/10.4103/ijmr.ijmr_1768_17

Leone N, Courbon D, Thomas F, Bean K, Jégo B, Leynaert B, et al. Lung function impairment and metabolic syndrome: The critical role of abdominal obesity. Am J Respir Crit Care Med. 2009;179(6):509–516. Available from: https://doi.org/10.1164/rccm.200807-1195oc

Zammit C, Liddicoat H, Moonsie I, Makker H. Obesity and respiratory diseases. Int J Gen Med. 2010;3:335–343. Available from: https://doi.org/10.2147/ijgm.s11926

Tanchenko OA, Naryshkina SV. Clinical and functional particularities of arterial stiffness under concomitant cardiopulmonary pathology. Bulletin Physiology and Pathology of Respiration. 2018;(67):83–92. Available from: http://dx.doi.org/10.12737/article_5a9f2b6c723c93.71757652

Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, et al. COPD Gene Investigators. Obesity is associated with increased morbidity in moderate to severe COPD. Chest. 2017;151(1):68–77. Available from: https://doi.org/10.1016/j.chest.2016.08.1432

Franssen FM, O'Donnell DE, Goossens GH, Blaak EE, Schols AM. Obesity and the lung: 5. Obesity and COPD. Thorax. 2008;63(12):1110–1117. Available from: https://doi.org/10.1136/thx.2007.086827

DeLapp DA, Glick C, Furmanek S, Ramirez JA, Cavallazzi R. Patients with obesity have better long-term outcomes after hospitalization for COPD exacerbation. COPD. 2020;17(4):373–377. Available from: https://doi.org/10.1080/15412555.2020.1781805

Zapatero A, Barba R, Ruiz J, Losa JE, Plaza S, Canora J, et al. Malnutrition and obesity: Influence in mortality and readmissions in chronic obstructive pulmonary disease patients. J Hum Nutr Diet. 2013;26(1):16–22. Available from: https://doi.org/10.1111/jhn.12088

Hancu A. Nutritional status as a risk factor in COPD. Maedica (Bucur). 2019;14(2):140–143. Available from: https://doi.org/10.26574/maedica.2019.14.2.140