Figure 1

Sotatercept in the Treatment of Pulmonary Arterial Hypertension: A Comprehensive Narrative Review of Mechanism, Efficacy and Future Directions

Niroshan Ranjan*, Ahmed Ahmed, Jordana Woods, Ramaneshwar Selvaraj, Mihir Patel, Yaman Dalati, Vidushan Sabanathan and Thanujan Thangadurai

Published: 09 May, 2025 | Volume 9 - Issue 1 | Pages: 014-022

jprr-aid1068-g001

Figure 1:

Mechanism of Action of Sotatercept in PAH. Sotatercept (blue) acts as a ligand trap, sequestering excess activin ligands (red) from binding to ActRIIA/B receptors, thereby rebalancing signaling toward BMP-mediated (green) antiproliferative pathways in pulmonary vascular cells.

Read Full Article HTML DOI: 10.29328/journal.jprr.1001068 Cite this Article Read Full Article PDF

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