Research Article

Effects of melatonin on liver and lung tissues of animals with bile duct ligation-induced hepatopulmonary syndrome

Adriane Dal Bosco, Josieli Raskopf Colares, Sílvia Bona, Lívia Barboza De Andrade, Luiz Alberto Forgiarini Jr., Aline Felicio Bueno, Alexandre Simões Dias* and Norma Anair Possa Marroni

Published: 13 October, 2021 | Volume 5 - Issue 1 | Pages: 097-105

The objective was to assess the antioxidant effect of melatonin (MLT) on liver and lung tissues of animals with bile duct ligation (BDL)-induced hepato-pulmonary syndrome (HPS). A model of BDL-induced biliary cirrhosis was used in male Wistar rats. Results suggest that MLT has an antioxidant effect on liver and lung tissues in animals with BDL-induced HPS by higher activity of antioxidant enzymes in the group HPS treated with MLT and the histological analysis of lung parenchyma showing decreased damage in this same group, including other analysis described below.

Read Full Article HTML DOI: 10.29328/journal.jprr.1001033 Cite this Article Read Full Article PDF


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