Case Report

Successful Therapy with intravenous gamma globulin in two children with postinfectious bronchiolitis obliterans

Sevgi Pekcan, Bahar Gökturk* and Ismail Reisli

Published: 23 June, 2017 | Volume 1 - Issue 1 | Pages: 009-012

Bronchiolitis obliterans (BO) is an infrequent clinical syndrome characterized by the chronic obstruction of small airways due to fibrosis [1]. Intravenous immunoglobulin (IVIG) could be used for treatment while underlying immune mechanisms in the pathogenesis of BO exist [2]. Here, we present two children with BO due to adenovirus infection whose complaints resolved after IVIG replacement.

Read Full Article HTML DOI: 10.29328/journal.jprr.1001003 Cite this Article Read Full Article PDF


  1. Champs NS, Lasmar LM, Camargos PA, Marguet C, Fischer GB, et al. Post-infectious bronchiolitis obliterans in children, J. Pediatr (Rio J). 2011; 87: 187-198. Ref.: https://goo.gl/7kT6cA
  2. Kim CK, Kim SW, Kim JS, Koh YY, Cohen AH, et al. Bronchiolitis obliterans in the 1990s in Korea and the United States. Chest. 2001; 120: 1101-1106. Ref.: https://goo.gl/H7qkaB
  3. Li YN, Liu L, Qiao HM, Cheng H, Cheng HJ. Post-infectious bronchiolitis obliterans in children: a review of 42 cases. BMC Pediatr. 2014; 25: 238. Ref.: https://goo.gl/CgmyWf
  4. Meyer KC, Raghu G, Verleden GM, Corris PA, Aurora P, et al. An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. Eur Respir J. 2014; 44: 1479-1503. Ref.: https://goo.gl/fdVnR1
  5. Moonnumakal SP, Fan LL. Bronchiolitis obliterans in children. Curr Opin Pediatr. 2008; 20: 272-278. Ref.: https://goo.gl/RkMPiQ
  6. Yates B, Murphy DM, Forrest IA, Ward C, Rutherford RM, et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2005; 172: 772-775. Ref.: https://goo.gl/heaBa5
  7. Verleden GM, Vanaudenaerde BM, Dupont LJ, Van Raemdonck DE. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2006; 174: 566-570. : https://goo.gl/h3bzJR
  8. Hayes D Jr. A review of bronchiolitis obliterans syndrome and therapeutic strategies. J Cardiothorac Surg. 2011; 6: 92. Ref.: https://goo.gl/NySiqB
  9. Nimmerjahn F, Ravetch JV. The antiinflammatory activity of IgG: the intravenous IgG paradox. J Exp Med. 2007; 204: 11-15. Ref.: https://goo.gl/pzNGSE
  10. Ibáñez C, Suñé P, Fierro A, Rodríguez S, López M, et al. Modulating effects of intravenous immunoglobulins on serum cytokine levels in patients with primary hypogammaglobulinemia. BioDrugs. 2005; 19: 59-65. Ref.: https://goo.gl/xHN12R


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